ZHANG Ying.Study on Optimization of the Extraction of Artemisinin[J].Northern Horticulture,2014,38(11):122-125.
青蒿素的提取工艺优化研究
- Title:
- Study on Optimization of the Extraction of Artemisinin
- 文章编号:
- 1001-0009(2014)11-0122-04
- Keywords:
- artemisinin; orthogonal experiments; extraction rate; optimal process
- 分类号:
- R 282. 71
- 文献标志码:
- A
- 摘要:
- 以干青蒿叶粉末为原料，以青蒿素提取量为考察指标，采用有机溶剂提取法，以料液比、温度、时间为考察因素，在单因素试验基础上进行了3因素3水平正交实验，研究提取青蒿素的最佳工艺条件。结果表明：青蒿素的最佳提取条件为料液比1∶20 g/mL，提取温度50℃,提取时间2.5 h,青蒿素提取量达5.27 mg/g。
- Abstract:
- Taking dry leaves of Artemisia annua L. as material and extracted yield of artemisinin as investigate indicator,artemisinin was extracted form dry leaves of Artemisia annua L.by using organic solvent methods.Material liquid ratio,extracting temperature and time were selected as experimental factors,orthogonal experiment was carried out on the basis of single factor experiments,in order to study the optimal extraction conditions of artemisinin.The results showed that the optimal conditions for artemisinin extraction were material-liquid ratio 1∶20 g/mL,extraction temperature 50℃ and extraction time 2.5 h,extracting amount of artemisinin was up to 5.27 mg/g.
参考文献/References:
[1] 孔建强,王伟,程克棣,等.青蒿素的合成生物学研究进展[J].药学学报,2013,48(2):193-205.
[2] 王满元.青蒿素类药物的发展历史[J].自然杂志,2012,34(1):44-47.
[3] 卢义钦.青蒿素的发现与研究进展[J].生命科学研究,2012,16(3):260-265.
[4] 梅林,石开云.青蒿素国内研究进展[J].激光杂志,2008,29(2):95-96.
[5] 凌立新,张国芬,姚晨.青蒿素提取工艺研究[J].亚太传统医药,2009,5(2):37-38.
[6] 张犇,王剑文.青蒿素检测方法的研究近况[J].抗感染药学,2008,5(4):201-204.
[7] 阚毓铭,黄泰康.中药化学实验操作技术[M].北京:中国医药科技出版社,1998.
[8] 梁晓媛,李隆云,白志川.青蒿中青蒿素提取工艺研究进展[J].重庆理工大学学报(自然科学),2013,27(2):32-38.
[9] 周毅峰,石开明,艾训儒,等.快速溶剂萃取法提取青蒿素条件研究[J].中药材,2008,31(2):296-298.
[10] 张玲,杜小英,姜锦花.蒿素提取分离工艺研究[J].现代中药研究与实践,2005,19(6):57-58.
相似文献/References:
[1]周金梅,赵文若,建德锋,等.不同品种和栽植密度及整枝方式对黄秋葵产量的影响[J].北方园艺,2013,37(04):34.
[2]刘晓莉,田海娟,钟容,等.盐沉淀法提取紫苏活性蛋白的工艺研究[J].北方园艺,2013,37(04):147.
[3]史艳财,邹 蓉,韦记青,等.黄花倒水莲总黄酮提取工艺研究[J].北方园艺,2014,38(12):134.
SHI Yan-cai,ZOU Rong,WEI Ji-qing,et al. Study on Extraction Condition of Flavonoid in Polygala fallax[J].Northern Horticulture,2014,38(11):134.
[4]叶 林,李春江,张光弟,等.不同育苗穴数、基质配比和施肥量对温室辣椒幼苗生长及其秧苗质量的影响[J].北方园艺,2014,38(13):50.
YE Lin,LI Chun-jiang,ZHANG Guang-di,et al.Effects of Different Seedling Number of Holes，Substrates and Fertilization on the Growth and Quality of Greenhouse Pepper Seedlings[J].Northern Horticulture,2014,38(11):50.
[5]杨申明,王振吉,沈继森.彝药猪鬃草中总黄酮提取工艺研究[J].北方园艺,2014,38(11):125.
YANG Shen-ming,WANG Zhen-ji,SHEN Ji-sen.Study of the Extraction Technology of Total Flavonoids in Adiantum capillus-veneris[J].Northern Horticulture,2014,38(11):125.
[6]王 嵩,马 杰,赵 维,等.黔西北景天三七高产栽培优化研究[J].北方园艺,2014,38(11):147.
WANG Song,MA Jie,ZHAO Wei,et al.Research on Optimazation Growing Cutivation of Sedum aizoon L. in Northwest Guizhou[J].Northern Horticulture,2014,38(11):147.
[7]王亚红,王亚丽,祝 波.瓦松总黄酮的索氏提取工艺研究[J].北方园艺,2014,38(10):130.
WANG Ya-hong,WANG Ya-li,ZHU Bo.Study on Soxhlet Extraction Technology of Total Flavonoids From Orostachys fimbriatus[J].Northern Horticulture,2014,38(11):130.
[8]杨艳俊,王一洋.微波辅助法提取景天三七中齐墩果酸的工艺研究[J].北方园艺,2014,38(10):152.
YANG Yan-jun,WANG Yi-yang.Study on Extraction Technology of Oleanolic Acid From Sedum aizoon L.[J].Northern Horticulture,2014,38(11):152.
[9]姜 喜,陈加利,肖 巍,等.扁桃茎段增殖培养基的筛选[J].北方园艺,2013,37(22):111.
JIANG Xi,CHEN Jia-li,XIAO Wei,et al.Screening of the Multiplying Medium of Almond Stem[J].Northern Horticulture,2013,37(11):111.
[10]郑 涛,苏 锐,赵韵美,等.青杄针叶多酚超声提取工艺的优化[J].北方园艺,2013,37(22):138.
ZHENG Tao,SU Rui,ZHAO Yun-mei,et al.Optimization of Ultrasonic Extraction of Polyphenols from the Leaves of Picea wilsonii[J].Northern Horticulture,2013,37(11):138.
备注/Memo
作者简介：张颖（1981-），女，重庆永川人，硕士，讲师，现主要从事生物分离与细胞工程等教学与科研工作。E-mail:zemn@sina.com.
基金项目：攀枝花学院创新资助项目 (2012YB03)。
收稿日期：2014-01-17