ZHANG Chengxu,ZHANG Chi.Research Progress on Biological Activity and Product Application of Selenium Enriched Cordyceps militaris[J].Northern Horticulture,2022,(10):124-129.[doi:10.11937/bfyy.20214884]
富硒蛹虫草的生物活性及产品应用研究进展
- Title:
- Research Progress on Biological Activity and Product Application of Selenium Enriched Cordyceps militaris
- 文献标志码:
- A
- 摘要:
- 富硒蛹虫草具有优良的保健功能，基于硒元素与蛹虫草的特殊生物活性，开发具有保健和药食作用的富硒蛹虫草产品，拥有广阔的发展前景和重要的社会、经济价值。该文概述了近年来蛹虫草有关富集硒、化学成分、生物活性以及产品开发等方面的研究进展，以期为硒和蛹虫草资源的综合利用提供参考依据。
- Abstract:
- Selenium enriched Cordyceps militaris has excellent health care function.Based on the special biological activity of selenium and Cordyceps militaris,the development of selenium enriched Cordyceps militaris products with health care,medicine and food has broad development prospects and important social and economic value.The research progress of Cordyceps militaris on selenium enrichment,chemical composition,biological activity and product development in recent years were summarized,in order to provide reference for the comprehensive utilization of selenium and Cordyceps militaris resources.
参考文献/References:
[1]JR A H,TINKER L,BOWEN D J,et al.Correlates of fat intake behaviors in participants in the eating for a healthy life study[J].Journal of the American Dietetic Association,2006,106(10):1605-1613.[2]JING Y,CUI X,CHEN Z,et al.Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris[J].Carbohydrate Polymers,2014,102(Complete):288-296.[3]YU R,SONG L,ZHAO Y,et al.Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris[J].Fitoterapia,2004,75(5):465-472.[4]ZHU L N,TANG Q J,ZHOU S et al.Isolation and purification of a polysaccharide from the caterpillar medicinal mushroom Cordyceps militaris (Ascomycetes) fruit bodies and its immunomodulation of RAW 264.7 macrophages[J].International Journal of Medicinal Mushrooms,2014,16(3):247-257.[5]董彩虹,李文佳,李增智,等.我国虫草产业发展现状、问题及展望：虫草产业发展金湖宣言[J].菌物学报,2016,35(1):1-15.[6]ALLMANG C,KROL A.Selenoprotein synthesis:UGA does not end the story[J].Biochimie,2006,88(11):1561-1571.[7]SCHWARZ K,FOLTZ C M.Factor 3 activity of selenium compounds[J].Journal of Biological Chemistry,1958,233(1):245-251.[8]YU Y,WEI J.Glutathione peroxidase and its synthesis mechanism[J].Acta Biophysica Sinica,2013,29(10):724.[9]熊传帅,张海波,张进明,等.硒和硒蛋白调节动物抗氧化功能及硒在畜牧生产中应用的研究进展[J].中国畜牧杂志,2021,57(10):59-64.[10]FENG R,ZHAO P,ZHU Y,et al.Application of inorganic selenium to reduce accumulation and toxicity of heavy metals (metalloids) in plants:The main mechanisms,concerns,and risks[J].Science of The Total Environment,2021,771:144776.[11]RAYMAN M P.The importance of selenium to human health[J].Lancet (London,England),2018,356(9225):233-241.[12]LIAO G,TANG J,WANG D,et al.Selenium nanoparticles (SeNPs) have potent antitumor activity against prostate cancer cells through the upregulation of miR-16[J].World Journal of Surgical Oncology,2020,18(1):81.[13]WANG X,XING Y N,CHEN Z Y,et al.Determination of 6 selenium species in selenium-enriched food by hyphenated technique of high performance liquid chromatography-inductively coupled plasma mass spectrometry[J].Chinese Journal of Analytical Chemistry (Chinese Version),2013,41(11):1669.[14]李红然.硒对蛹虫草菌生长及代谢影响研究[D].天津：天津科技大学,2019.[15]马国良,马琪,看措,等.不同浓度硒对蛹虫草菌丝生长发育的影响[J].安徽农业科学,2011,39(30):18539-18541,18547.[16]杜双田,辛亚平,阳经慧,等.亚硒酸钠对蛹虫草生长及子座硒含量的影响[J].西北农林科技大学学报(自然科学版),2012,40(7):209-214.[17]张园园,王勇,张晶,等.蛹虫草、白化蛹虫草菌丝硒耐受性比较研究[J].食用菌,2020,42(4):20-23.[18]张曦文,赵博,张国财,等.富硒对蛹虫草菌丝干重及胞内酶活性的影响[J].食品工业科技,2017,38(14):151-155.[19]HU T,LIANG Y,ZHAO G,et al.Selenium biofortification and antioxidant activity in Cordyceps militaris supplied with selenate,selenite,or selenomethionine[J].Biological Trace Element Research,2019,187(2):553-561.[20]DONG J Z,LIU M R,LEI C,et al.Effects of selenium and light wavelengths on liquid culture of Cordyceps militaris link[J].Applied Biochemistry and Biotechnology,2012,166(8):2030-2036.[21]邵颖,袁凤健,陈安徽,等.富硒蛹虫草活性成分及抗氧化作用分析[J].食品工业,2013,34(4):126-129.[22]CUNNINGHAM K G,MANSON W,SPRING F S,et al.Cordycepin,a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link[J].Nature,1950,166(4231):949.[23]GUAN H,LI H,LI Q,et al.Efficient production of cordycepin during submerged liquid fermentation by Cordyceps militaris coupled with macroporous resin adsorption[J].CIESC Journal,2019,70(7):2675-2683.[24]LIU F,ZHU Z Y,SUN X,et al.The preparation of three selenium-containing Cordyceps militaris polysaccharides:Characterization and anti-tumor activities[J].International Journal of Biological Macromolecules,2017,99:196-204.[25]黄海辰,吴文雅,戚梦,等.虫草素抗三阴性乳腺癌的转录组学分析[J].生物技术通报,2021,37(11):72-80.[26]UEN W C,SHI Y C,CHOONG C Y,et al.Cordycepin suppressed lipid accumulation via regulating AMPK activity and mitochondrial fusion in hepatocytes[J].Journal of Food Biochemistry,2018,42(5):e12569.[27]WEN Z,DU X,MENG N,et al.Tussah silkmoth pupae improve anti-tumor properties of Cordyceps militaris (L.) Link by increasing the levels of major metabolite cordycepin[J].RSC Advances,2019,9(10):5480-5491.[28]汪晶,马丹钰,陈旺.虫草素的合成研究进展[J].化学通报,2021,84(8):787-792.[29]王鹏跃,曾议霆,李小军.虫草及其制品中D-甘露醇检测技术研究进展[J].食品工业科技,2018,39(18):347-352.[30]周绍琴,王乐乐,吴映梅,等.不同固态培养基对蛹虫草子实体品质的影响[J].中国酿造,2021,40(4):100-104.[31]努尔买买提.蛹虫草的人工培育及其多糖抗肿瘤活性研究[D].长春：东北师范大学,2020.[32]ZHU Z Y,LIU X C,DONG F Y,et al.Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris[J].Applied Microbiology and Biotechnology,2016,100(9):3909-3921.[33]邵波,李英,王效琰,等.蛹虫草多糖促进CETP-tg小鼠胆固醇逆转运[J].中国病理生理杂志,2020,36(10):1754-1760.[34]卫银,侯笑笑,杜笑,等.蛹虫草胞外多糖的提取工艺优化及其抗结肠癌活性研究[J].山西农业大学学报(自然科学版),2020,40(6):121-128.[35]江琦.蛹虫草多糖和虫草素的提取分离及活性研究[D].无锡：江南大学,2018.[36]宗雯雯,沈照鹏,卜义明,等.蛹虫草多糖单糖组成的方法学研究[J].菌物学报,2018,37(3):395-404.[37]YU X Y,ZOU Y,ZHENG Q W,et al.Physicochemical,functional and structural properties of the major protein fractions extracted from Cordyceps militaris fruit body[J].Food Research International,2021,142:110211.[38]郭长春.蛹虫草蛋白提取物对D-Gal诱导衰老模型小鼠的作用及其机制研究[D].吉林：北华大学,2019.[39]ZHANG C,HUANG Q.A preliminary study on the antioxidant activity of selenoprotein in Cordyceps militaris rich in selenium[J].Advanced Materials Research,2011,396/397/398:157-161.[40]董亮,何永志,王远亮,等.超氧化物歧化酶(SOD)的应用研究进展[J].中国农业科技导报,2013,15(5):53-58.[41]REN Y,SUN P,LI H,et al.Effects of Na2SeO3 on growth,metabolism,antioxidase and enzymes involved in polysaccharide synthesis of Cordyceps militaris[J].Process Biochemistry,2020,97:64-71.[42]ZHU Z Y,LIU F,GAO H,et al.Synthesis,characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris[J].International Journal of Biological Macromolecules,2016,93:1090-1099.[43]孙军德,侯静,杨逸.富硒蛹虫草多糖对鱼藤酮诱导伤害果蝇的保护功效[J].食品科学,2013,34(7):266-269.[44]赵博.蛹虫草富硒条件培养优化及硒多糖活性机理的研究[D].哈尔滨：东北林业大学,2017.[45]谭许朋,梁慧嘉,恽昊,等.富硒蛹虫草对高尿酸血症小鼠的影响[J].食用菌学报,2018,25(3):49-55.[46]朱蕴兰,陈宏伟,张城.富硒蛹虫草胞内多糖对自由基的清除作用[J].农业工程,2011,1(3):53-57.[47]TAO X,NING Y,ZHAO X,et al.The effects of cordycepin on the cell proliferation,migration and apoptosis in human lung cancer cell lines A549 and NCI-H460[J].Journal of Pharmacy and Pharmacology,2016,68(7):901-911.[48]ZENG H,COMBS G F.Selenium as an anticancer nutrient:Roles in cell proliferation and tumor cell invasion[J].The Journal of Nutritional Biochemistry,2008,19(1):1-7.[49]LUO L,RAN R,YAO J,et al.Se-enriched Cordyceps militarisinhibits cell proliferation,induces cell apoptosis,and causes G2/M phase arrest in human non-small cell lung cancer cells[J].Onco Targets and Therapy,2019(12):8751-8763.[50]钟鸣,王丽贺,马慧,等.富硒蛹虫草提取物硒蛋白多糖对荷瘤小鼠的影响[J].中国中药杂志,2008(18):2120-2123.[51]陈金林.富硒蛹虫草胶囊对肿瘤、免疫功能的观察[J].北方药学,2012,9(5):66-67.[52]钟鸣,高丹,胡昆,等.富硒蛹虫草对小鼠降血脂和抗氧化作用的影响[J].时珍国医国药,2009,20(12):3142-3144.[53]HU S,WANG J,LI F,et al.Structural characterisation and cholesterol efflux improving capacity of the novel polysaccharides from Cordyceps militaris[J].International Journal of Biological Macromolecules,2019,131:264-272.[54]YU M L,YUE J,HUI N,et al.Anti-hyperlipidemia and gut microbiota community regulation effects of selenium-rich Cordyceps militaris polysaccharides on the high-fat diet-fed mice model[J].Foods,2021,10(10):2252.[55]邵波,刘伯言,陈刘欣,等.蛹虫草多糖降胆固醇作用的机制探讨[J].中国动脉硬化杂志,2020,28(10):861-866.[56]焦春伟,何春艳,马晓伟,等.一种富硒蛹虫草压片糖果及其制备方法[P].中国:CN111887333A,2020-11-06.[57]周保福.一种富硒蛹虫草鱼油夹心糖果[P].中国：CN107373002A,2017-11-24.[58]孙备宽.一种富硒虫草阿胶及阿胶糕的生产方法[P].中国：CN105996010A,2016-10-12.[59]聂威.一种富硒蛹虫草面条及其制备方法[P].中国:CN111280380A,2020-06-16.[60]林标声,罗茂春.蛹虫草-山楂复合保健饮料的研制[J].食品科学,2013,34(4):293-297.[61]郭岩彬,胡婷,文雪妮,等.具有护肝功能的富硒蛹虫草酒及其制备方法[P].中国:CN110591865A,2019-12-20.[62]李海洲,陈正余,张京国,等.安康富硒蛹虫草黄酒生产工艺探讨[J].安康学院学报,2015,27(6):71-73.
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备注/Memo
第一作者简介：张承旭（1998-），男，硕士研究生，研究方向为微生物硒资源。E-mail:1326755668@qq.com.责任作者：张驰（1965-），男，硕士，教授，现主要从事植物生物化学及硒资源等研究工作。E-mail:zhtzu@163.com.基金项目：国家自然科学基金资助项目（81402225）；硒食品营养与健康湖北省工程研究中心开放资助项目（PT082008）；湖北民族大学生物科学与技术学院研究生创新计划资助项目。收稿日期：2021-12-01