[1]马丽,张春庆.RNA干扰机制及应用研究进展[J].北方园艺,2012,36(10):191-193.
　MA Li,ZHANG Chun-qing.Mechanism of RNA Interference and Progress of its Application[J].Northern Horticulture,2012,36(10):191-193.
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RNA干扰机制及应用研究进展

《北方园艺》[ISSN:1001-0009/CN:23-1247/S] 卷: 第36卷 期数: 2012年10期 页码: 191-193 栏目: 出版日期: 2012-10-16
Title:
Mechanism of RNA Interference and Progress of its Application
文章编号:
1001-0009（2012）10-0191-03
作者:
马丽1; 张春庆2
1.枣庄学院 生命科学学院，山东 枣庄 277160；
2.山东农业大学 农学院，山东 泰安 271000
Author(s):
MA Li1 ; ZHANG Chun-qing2
1.Department of Life Science,Zaozhuang College,Zaozhuang,Shangdong 277160；
2.College of Agronomy，Shandong Agricultural University,Tai’an,Shangdong 271000
关键词:
RNA干扰; dsRNA; 转录后基因沉默
Keywords:
RNA interference;  double strand RNA;  post-transcriptional gene silencing
分类号:
Q 946-33
文献标志码:
A
摘要:
RNA干扰是外源和内源的双链RNA（double-strand RNA，dsRNA）特异性诱导生物体内同源靶基因mRNA的降解，从而导致转录后基因沉默的现象。目前对于RNA干扰机制已有深入研究，同时RNA干扰在抑制有害基因表达、功能基因组学及基因治疗等方面的应用研究也取得了较大进展。现主要综述了RNA干扰的作用机制、作用特点和技术应用等方面的研究进展。
Abstract:
RNA interference is the process of the post-transcriptional gene silencing in which it degraded endogenous mRNA specifically by the mediation of corresponding double stranded RNA.Many studies on the mechanism of RNA interference were made.RNAi provided a new tool for studing gene function，gene therapy and inhibit the expression of unfavorable genes.The mechanism，the characteristics and application of RNAi were reviewed in this paper.

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备注/Memo

第一作者简介：马丽（1980-），女，博士，副教授，研究方向为植物基因工程。E-mail：mary1976816@163.com。
基金项目：转基因生物新品种培育重大专项资助项目（2009ZX08003-014B）；枣庄学院博士科研启动基金资助项目。
收稿日期：2012-03-05

更新日期/Last Update: 2014-09-09