YU Lian,LIU Si-jia,DU Yan,et al.Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release[J].Northern Horticulture,2012,36(19):175-178.
水飞蓟素固体脂质纳米粒的制备及体外释放研究
- Title:
- Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release
- 文章编号:
- 1001-0009(2012)19-0175-04
- 分类号:
- S 567.9
- 文献标志码:
- A
- 摘要:
- 以单硬脂酸甘油酯为脂质材料，豆磷脂与泊洛沙姆188为乳化剂，水飞蓟素为试验药材，采用乳化-超声分散法制备SM-SLN胶体溶液，对其粒径、形态、包封率和载药量及体外释放进行研究，并对其稳定性进行研究。结果表明：所制得的纳米粒外观形态圆整，平均粒径为150.6 nm，平均包封率为85.3%。乳化-超声分散法适用于SM-SLN的制备，其制剂包封率高，粒度分布较均匀，具有较好的稳定性。
- Abstract:
- Taking monostearin lipid as material，soybean lecithin and poloxamer 188 as emulsifier，silymarin as a model drug，SM-SLN were prepared by the emulsification ultrasonic dispersion method.The particle size，morphology，encapsulation efficiency，drug loading，in vitro release and stability were studied.The results showed that morphology of SM-SLN was round and smooth，and the average particle size was 150.6 nm and encapsulation efficiency 85.3%.Emulsification ultrasonic dispersion method was suitable for SM-SLN preparation，with high encapsulation efficiency，uniform particle size distribution and better stability.
参考文献/References:
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备注/Memo
第一作者简介：于莲(1961-)，女，本科，教授，研究方向为微生态及缓控释靶向制剂。E-mail:jdyulian@163.com.