LIU Sasa,ZHANG Yupeng,YANG Yuhang,et al.Research Progress on Pharmacology and Resource Development of Prunus mume[J].Northern Horticulture,2026,(13):132-137.[doi:10.11937/bfyy.20254411]
乌梅的药理作用及资源开发研究进展
- Title:
- Research Progress on Pharmacology and Resource Development of Prunus mume
- 文章编号:
- 1001-0009(2026)13-0132-06
- 分类号:
- S853.75
- 文献标志码:
- A
- 摘要:
- 乌梅(Prunus mume)为蔷薇科植物梅的干燥近成熟果实,是兼具药用价值与食用功能的传统药食同源中药材,应用历史悠久。随着大健康产业的蓬勃发展,乌梅在功能性食品与饮料领域的应用范围持续拓展,衍生出乌梅泡腾片、复合果蔬饮料、发酵果酒等多样化产品形态。该文系统梳理乌梅的化学成分与现代药理作用研究进展,重点综述其在食品加工领域的关键技术优化路径与产业化应用现状,并对未来研究方向进行展望,旨在为乌梅资源的深度开发、高值化利用提供全面且系统的参考依据。
- Abstract:
- Prunus mume is the dried,nearly mature fruit of the plant Prunus mume Sieb.et Zucc.(family Rosaceae).As a traditional Chinese medicinal and edible homologous substance,it has been valued for both its therapeutic and nutritional functions throughout a long history of application.With the vigorous development of the comprehensive health industry,the application scope of Prunus mume in functional foods and beverages has continuously expanded,leading to the development of diversified product forms such as effervescent tablets,compound fruit and vegetable beverages,and fermented fruit wines.The research advances in the chemical constituents and modern pharmacological activities of Prunus mume were systematically reviewed.A particular focus was placed on summarizing the optimized approaches for key processing technologies and the current status of its industrial application in the food sector.Future research directions were also prospected,in order to provide comprehensive and systematic theoretical references for the in-depth development and high-value utilization of Prunus mume resources.
参考文献/References:
[1]国家药典委员会.中华人民共和国药典-一部:2005年版[M].北京:化学工业出版社,2005.[2]张子玥,孙士玲,关徐涛,等.乌梅药理作用及其药对研究进展[J].江苏中医药,2026,58(1):77-81.[3]张君成,梁华,王燕,等.乌梅药理作用研究进展[J].辽宁中医药大学学报,2021,23(8):122-126.[4]赖菁华,杨晓雯.响应面法优化乌梅泡腾片的配方[J].食品工业,2020,41(4):91-95.[5]左亚锋,王成,李艳冉,等.响应面法优化乌梅复合饮料的制备工艺[J].赤峰学院学报(自然科学版),2022,38(9):21-28.[6]陈战国,恩伯提,张志琪.RP-HPLC同时测定乌梅中8种有机酸含量[J].中国中药杂志,2006,31(21):1783-1786.[7]彭悦云,朱文涛,张庆莲,等.乌梅中柠檬酸的测定和提取工艺的优化[J].华西药学杂志,2011,26(1):59-61.[8]丁超.乌梅在熏制过程中色泽和风味物质的变化及其应用研究[D].广州:华南理工大学,2012.[9]肖悦,姜雅轩,柏钰晶,等.软枣猕猴桃叶片和根中黄酮类化合物提取方法的研究[J].北方园艺,2025(21):51-61.[10]吴贤波,董培智,周海,等.基于HPLC-MS和主成分分析的乌梅血清药物化学研究[J].中国实验方剂学杂志,2014,20(24):118-122.[11]刘泽峰,穆晓红,王兴海.乌梅果仁的营养价值研究及利用前景[J].食品研究与开发,2014,35(22):148-149.[12]耿飞,王伟,周涛.乌梅提取液对李斯特菌的抑菌机理[J].食品科学,2011,32(15):88-93.[13]吴传茂,吴周和,陈士英.乌梅提取液的抑菌作用研究[J].食品工业,2000,21(3):11-13.[14]周茜,王唯霖,郭晓晓,等.乌梅醇提物对金黄色葡萄球菌的抑制作用[J].食品研究与开发,2016,37(15):34-37.[15]杨莹菲,胡汉昆,刘萍,等.乌梅抗氧化作用的实验考察[J].中国医院药学杂志,2012,32(9):664-667.[16]邓婉婷,管淑玉,李瑶,等.乌梅总有机酸的提取优化工艺及其抗氧化活性研究[J].广东药学院学报,2015(2):171-175.[17]PARK C,JIN C Y,KIM G Y,et al.Induction of apoptosis by ethanol extract of Prunus mume in U937 human leukemia cells through activation of caspases[J].Oncology Reports,2011,26(4):987-993.[18]徐超.乌梅提取物预防大肠癌发生发展的实验研究[D].南京:南京中医药大学,2016.[19]肖刚,杨树森,司明明,等.基于多组学分析乌梅丸抑制脂肪酸代谢重编程防治结直肠癌的作用机制[J].中国实验方剂学杂志,2026,32(9):21-30.[20]向润清,范源.熊果酸及其衍生物抗肿瘤作用的研究进展[J].药学研究,2019,38(2):63-69.[21]王璐,张红宇,王莉.乌梅及其不同炮制品的药理作用比较[J].中药材,2010,33(3):353-356.[22]武天琦,桑希生.乌梅有效成分对2型糖尿病的作用机制及相关研究进展[J].中医药学报,2025,53(4):108-113.[23]LEE N K,SOWA H,HINOI E,et al.Endocrine regulation of energy metabolism by the skeleton[J].Cell,2007,130(3):456-469.[24]王秀英,李淑华,胡东芳,等.乌梅对照品:熊果酸降脂作用试验研究[J].辽宁中医药大学学报,2011,13(12):12-13.[25]陈仲新,资晓红,刘爱文,等.山楂乌梅降脂茶对高脂血症大鼠血脂和血液流变学的影响[J].中医药导报,2007,13(9):71-72.[26]NOMURA S,KONO R,IMAOKA M,et al.Traditional Japanese apricot (Prunus mume) induces osteocalcin in osteoblasts[J].Bioscience,Biotechnology,and Biochemistry,2022,86(4):528-534.[27]陈林,陈鸿平,刘友平,等.乌梅不同部位药理作用研究[J].中国药房,2007,18(27):2089-2090.[28]黎同明,高洁,王桂香.乌梅水煎液镇静催眠及抗惊厥作用实验研究[J].中医学报,2011,26(7):818-820.[29]吴贤波,朱海燕,李向,等.基于蛋白酶激活受体2表达研究药对防风-乌梅抗过敏的配伍机制[J].北京中医药大学学报,2015,38(10):682-685.[30]朱海燕,吴贤波,金贤国,等.酸味中药乌梅对肥大细胞脱颗粒及相关信号传导通路的影响[J].时珍国医国药,2015,26(9):2096-2098.[31]NA J R,KIM E,NA C S,et al.Citric acid-enriched extract of ripe Prunus mume (siebold) siebold & zucc.induces laxative effects by regulating the expression of aquaporin 3 and prostaglandin E(2) in rats with loperamide-induced constipation[J].Journal of Medicinal Food,2022,25(1):12-23.[32]苗小雨,王亚静,赵鑫,等.乌梅散对菌群失调性腹泻小鼠肠道乳糖酶活性及菌群多样性的影响[J].中国实验方剂学杂志,2023,29(4):33-42.[33]WANG J,DING K,WANG Y,et al.Wumei pill ameliorates AOM/DSS-induced colitis-associated colon cancer through inhibition of inflammation and oxidative stress by regulating S-adenosylhomocysteine hydrolase- (AHCY-) mediated hedgehog signaling in mice[J].Oxidative Medicine and Cellular Longevity,2022,2022(1):4061713.[34]张理平,王英豪,张海燕,等.乌梅抑制黑色素的机制[J].福建中医药大学学报,2011,21(5):12-14.[35]张理平,梁娟,陈彬,等.22味酸味药性中药提取物影响黑素合成的实验研究[J].中国中西医结合杂志,2015,35(5):618-622.[36]谢琼,刘瑞.玫瑰花红枣乌梅复合饮料工艺研究[J].食品安全导刊,2022(15):121-124.[37]方元平,朱孟良,项俊.乌梅绿豆沙复合保健饮料的研制[J].北方园艺,2008(10):191-193.[38]苏凡.发酵型梅酒的工艺优化及品质分析[D].成都:西华大学,2021.[39]蒋桂芳,敖单一.青梅果酒发酵工艺研究[J].酿酒科技,2020(12):49-53.[40]吴妙鸿,邱珊莲.青梅酒发酵关键技术研究进展[J].农产品加工,2022(4):65-69,72.[41]彭家伟,曹荣冰,刘幼强.青梅酒加工工艺及相关技术研究进展[J].酿酒科技,2022(6):94-98.[42]田甜甜.青梅酒酿酒酵母的选育及耐酸机制解析[D].无锡:江南大学,2020.[43]PORTARO L,MAIOLI F,CANUTI V,et al.Schizosaccharomyces japonicus/Saccharomyces cerevisiae mixed starter cultures:New perspectives for the improvement of Sangiovese aroma,taste,and color stability[J].LWT,2022,156:113009.[44]CHEN K,LIU C,WANG Y,et al.Predominance of indigenous non-Saccharomyces yeasts in the traditional fermentation of greengage wine and their significant contribution to the evolution of terpenes and ethyl esters[J].Food Research International,2021,143:110253.
相似文献/References:
[1]黄英,刘晓博,司辉清,等.腊梅花精油的提取方法与应用前景[J].北方园艺,2013,37(04):188.
[2]常桂英,孙立梅,赵 雪,等.长白山刺果甘草与甘草化学成分的比较研究[J].北方园艺,2014,38(10):146.
CHANG Gui-ying,SUN Li-mei,ZHAO Xue,et al.Comparative Study on the Chemical Constituents of Changbai Mountain Glycyrrhiza pallidiflora and Glycyrrhiza uralensis [J].Northern Horticulture,2014,38(13):146.
[3]马赛,刘洪章.人参的研究及展望[J].北方园艺,2013,37(15):205.
MA Sai,LIU Hong-zhang.Research and Prospects of Ginseng[J].Northern Horticulture,2013,37(13):205.
[4]赵丽,杨光东,廉美兰,等.黄檗研究现状与展望[J].北方园艺,2013,37(15):212.
ZHAO Li,YANG Guang-dong,LIAN Mei-lan,et al.Status and Prospect of Research on Phellodendron amurense Rupr.[J].Northern Horticulture,2013,37(13):212.
[5]孙爱群,左经会,林长松,等.六盘水市龙胆科植物资源及药用价值研究[J].北方园艺,2012,36(02):178.
SUN Ai-qun,ZUO Jing-hui,LIN Chang-song,et al.Study on Resources and Medicinal Values of Gentianaceae Plants in Liupanshui Areas[J].Northern Horticulture,2012,36(13):178.
[6]陈 刚,杨玉珍,马 晓.香椿化学成分与保健功能研究进展[J].北方园艺,2013,37(20):189.
CHEN Gang,YANG Yu-zhen,MA Xiao.Research Progress on Chemical Composition and Health Function of Toona sinensis Roem[J].Northern Horticulture,2013,37(13):189.
[7]唐 雯,王建军,徐家星,等.槭树科药用植物的化学成分研究进展[J].北方园艺,2012,36(18):194.
TANG Wen,WANG Jian-jun,XU Jia-xing,et al.Advances of Chemical Composition of Medicinal Plants in Aceraceae[J].Northern Horticulture,2012,36(13):194.
[8]张烨,李晓飞,杨丽,等.紫茎泽兰色素化学成分初步研究[J].北方园艺,2012,36(23):23.
ZHANG Ye,LI Xiao-fei,YANG Li,et al.Preliminary Test of the Chemical Components of Pigment Extracted from Eupatorium adenophorum Spreng[J].Northern Horticulture,2012,36(13):23.
[9]王欢,王志,杜凤国.珍稀植物天女木兰研究进展[J].北方园艺,2012,36(21):184.
WANG Huan,WANG Zhi,DU Feng-guo.The Research Progress of Rare Plant Magnolia sieboldii[J].Northern Horticulture,2012,36(13):184.
[10]郑志新,金亚征,耿浩林.不同栽培方式下鼓槌石斛化学成分的测定[J].北方园艺,2013,37(23):168.
ZHENG Zhi-xin,JIN Ya-zheng,GENG Hao-lin.Determination of Chemical Constituents of Dendrobium chrysotoum Under Different Cultivation Modes[J].Northern Horticulture,2013,37(13):168.
备注/Memo
第一作者简介:刘洒洒(1992-),女,博士,副教授,现主要从事农产品加工与贮藏等研究工作。E-mail:sasaliu522@163.com.基金项目:达州市科技计划资助项目(22YYJC0002),四川革命老区发展研究中心课题资助项目(SLQ2025SD-30)。收稿日期:2025-12-24