[1]雷桅,税晓容,胡侃.黄芩苷生物合成途径与生物技术研究进展[J].北方园艺,2014,38(22):185-189.
　LEI Wei,SHUI Xiao-rong,HU Kan.Study Advance on Biosynthesis Pathway and Biotechnology of Baicalin[J].Northern Horticulture,2014,38(22):185-189.
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黄芩苷生物合成途径与生物技术研究进展

《北方园艺》[ISSN:1001-0009/CN:23-1247/S] 卷: 第38卷 期数: 2014年22期 页码: 185-189 栏目: 出版日期: 2014-11-30
Title:
Study Advance on Biosynthesis Pathway and Biotechnology of Baicalin
文章编号:
1001-0009（2014）22-0185-05
作者:
雷桅1; 税晓容2; 胡侃3
1.广东医学院 心血管疾病研究室,广东 湛江 524001；
2.广东医学院 血管外科研究室，广东 湛江 524001；
3.广东省农业厅 种子管理总站，广东 广州 510500
Author(s):
LEI Wei1; SHUI Xiao-rong2; HU Kan3
1.Laboratory of Cardiovascular Diseases,Guangdong Medical College,Zhanjiang,Guangdong 524001;
2.Laboratory of Vascular Surgery,Guangdong Medical College,Zhanjiang,Guangdong 524001;
3.Seed Management Station,Guangdong Province Department of Agriculture,Guangzhou,Guangdong 510500
关键词:
黄芩; 黄芩苷; 生物合成; 生物技术; 关键酶
Keywords:
Scutellaria sp.; baicalin; biosynthesis; biotechnology; key enzyme
分类号:
S 567；Q 946
文献标志码:
A
摘要:
黄芩苷是我国传统中药黄芩的主要黄酮类活性成分，具有很高的药用价值。近年来，随着植物次生代谢工程的发展，黄芩苷生物技术的研究也取得了重要成果。文章介绍了黄芩苷生物合成途径的关键酶，以及利用基因工程和生化技术进行代谢调控和遗传改良方面的最新进展，以期为黄芩苷优质药源的种质创新和分子育种提供参考。
Abstract:
Baicalin is the main active ingredient belonging to flavonoids from the traditional Chinese medicine Scutellaria sp.,which possesses high medicinal value.In recent years,with the development of plant secondary metabolic engineering,there were some important advances about the studies on the baicalin biotechnology.In this paper,the key enzymes involved in the biosynthesis pathway of baicalin,the last progress of metabolic regulation and genetic modification based on gene engineering and biochemical techniques were reviewed,aiming to provide theoretical references for germplasm innovation and molecular breeding of high-quality resource of baicalin.

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备注/Memo

第一作者简介：雷桅（1982-），男，湖北武汉人，博士，现主要从事天然药物生物技术与药理活性评价等研究工作。E-mail:thdmast@gmail.com.

基金项目：国家自然科学基金资助项目（81300035,81403044）；广东省自然科学基金资助项目（S2013040012115）。
收稿日期：2014-07-24

更新日期/Last Update: 2014-12-13