‘Hongyun 721’ is a new F1 hybrid of tomato,developed by crossing 1002A as female parent and LQH as male parent. It is indeterminate,mid-late maturity. Fruits are rounded,red,no green shoulders,firm,tolerant to storage and transportation with high commercial fruit rate. Average fruit weight is about 150 g. It is resistant to TMV and Fusarium wilt. Average yield is 72.0 t?hm-2. It is suitable for open and protected field cultivation in spring.