Cucumber ‘Jinyan No.1’ was used as test materials,the orthogonal design L9（34） of neutral-alkaline salt was designed to research the effect of organic silicon on malondialdehyde content in cucumber leaves spraying at different growth stages in pot experiments.The results showed that,under the neutral-alkaline salt stress,the content of malondialdehyde in leaves increased significantly,and increased gradually with the increase of the solution concentration.The effect of different neutral-alkaline salt content on the malondialdehyde content in cucumber leaves was the most significant at each stage and the alkaline salt were the main factors to change MDA content in cucumber leaves.The content of malondialdehyde in the leaves was significantly decreased which dealed with spyaying the organic silicone solution,indicating that the organic silicone had a mitigating effect on neutral-alkaline salt stress.