|Table of Contents|

Research Progress on Pharmacological Activity and Preparation Methods of Ginsenoside Rd(PDF)

《北方园艺》[ISSN:1001-0009/CN:23-1247/S]

Issue:
2015年23
Page:
202-205
Research Field:
Publishing date:

Info

Title:
Research Progress on Pharmacological Activity and Preparation Methods of Ginsenoside Rd
Author(s):
LU Chengwen1YIN Yongguang2
(1.College of Life Science,Changchun Normal University,Changchun,Jilin 130032;2.College of Biological and Agricultural Engineering,Jilin University,Changchun,Jilin 130022)
Keywords:
ginsenoside Rdpharmacological activitypreparation methods
PACS:
-
DOI:
10.11937/bfyy.201523055
Abstract:
As a main active monomer in ginseng,protopanaxadiol type saponin Rd had cardiovascular system protection,nervous system protection,anti-aging and anti tumor effects.As lower content of ginsenoside Rd in ginseng,it was difficult to extract ginsenoside Rd from gingseng root directly.Rare ginsenoside Rd by transforming glucosyl in high content ginsenoside,including chemical conversion method and biotransformation method were obtained.In order to provide a theoretical basis for the application of ginsenoside Rd,the pharmacological effects and preparation methods of ginsenoside Rd were summarized.

References:

 

[1]王铁生.中国人参[M].沈阳:辽宁科学技术出版社,2001:671-1036.

[2]RUDAKEWICH M,BA F,BENISHIN C G.Neurotrophic and neuroprotective actions of ginsenosides Rb1 and Rg1[J].Planta Medica,2001,67(6):533-537.

[3]FUZZATI N.Analysis methods of ginsenosides[J].Journal of Chromatography B,2004,812(1)119-133.

[4]WANG Y,LI X,WANG X,et al.Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway[J].PLOS One,2013,8(8):e70956.

[5]刘玉莲.人参皂苷Rb组单体和Rd对心肌缺血干预作用及机制的研究[D].长春:吉林大学,2009.

[6]李玲.人参皂苷Rd对阿尔茨海默病模型的神经保护作用及机制探讨[D].西安:中国人民解放军第四军医大学,2012.

[7]ZHANG C,DU F,SHI M,et al.Ginsenoside Rd protects neurons against glutamate-induced excitotoxicity by Inhibiting Ca influx[J].Cellular and Molecular Neurobiology,2012,32(1):121-128.

[8]YOKOZAWA T,OWADA S.Effects of ginsenoside Rd cephaloride-induced renal disorder[J].Nephron,1999,81(2):200-207.

[9]YOKOZAWA TLIU Z W.The role of ginsenoside Rd in cisplatin-induced acute renal failure[J].Renal Failure200022(2):115-127.

[10]YOKOZAWA T,DONG E.Role of ginsenoside-Rd in cisplatin-induced renal injury:special reference to DNA fragmentation[J].Nephron,2001,89(4):433-438.

[11]JEONG H G,POKHAREL Y R,HAN E H,et al.Induction of cyclooxygenase-2 by ginsenoside Rd via activation of CCAAT-enhancer binding proteins and cyclic AMP response binding protein[J].Biochemical and Biophysical Research Communications,2007,359(1):51-56.

[12]ZHANG Y X,WANG L,XIAO E L,et al.Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo[J].International Immunopharmacology,2013,17(4):1094-1100.

[13]YOKOZAWA T,SATOH A,CHO E J.Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice[J].Journal of Pharmacy and Pharmacology,2004,56(1):107-113.

[14]KIM B J.Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells[J].Journal of Ginseng Research,2013,37(2):201-209.

[15]朱春燕.人参皂苷Rd抑制非小细胞肺癌的生长及其作用机制[D].南京:南京中医药大学,2014.

[16]POKHARELl Y R,KIM N D,HAN H K,et al.Increased ubiquitination of multidrug resistance 1 by ginsenoside Rd[J].Nutrition and Cancer,2010,62(2):252-259.

[17]YANG Z G,CHEN A Q,SUN H X,et al.Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice[J].Vaccine,2007,25(1):161-169.

[18]LI G X,LIU Z Q.The protective effects of ginsenosides on human erythrocytes against hemirrinduced hemolysis[J].Food and Chemical Toxicology,2008,46(3):886-892.

[19]HAN Y,RHEW K Y.Ginsenoside Rd induces protective anti-Candida albicans antibody through immunological adjuvant activity[J].International Immunopharmacology,2013,17(3):651-657.

[20]杨菲,张统一,白录军.人参皂苷Rd通过调节SNI大鼠背根神经节钠、钾电流抑制痛敏[J].现代生物医学进展,2014,14(12):2214-2218.

[21]CHOI S S,LEE J K,SUN H W.Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse[J].Biological and Pharmaceutical Bulletin,2003,26(6):858-861.

[22]TAMURA T,CUI X,SAKAGUCHI N,et al.Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis[J].Food and Chemical Toxicology,2008,46(9):3080-3089.

[23]JI Q C,HARKEY M R,HENDERSON G L,et al.Quantitative determination of ginsenosides by high-performance liquid chromatography tandem mass spectrometry[J].Phytochemical Analysis,2001,12(5):320-326.

[24]HAN B H,PARK M H,HAN Y N,et al.Degradation of ginseng saponins under mild acidic conditions[J].Planta Medica,1982,44(3):146-149.

[25]王玉堂,李绪文,金海燕,.人参中人参皂苷的直接高压微波辅助降解[J].高等学校化学学报,2007,28(12):2264-2269.

[26]HONG H,CUI C H,KIM J K,et al.Enzymatic biotransformation of ginsenoside Rb1 and gypenoside XVII into ginsenosides Rd and F2 by recombinant β-glucosidase from Flavobacterium johnsoniae[J].Journal of Ginseng Research,2012,36(4):418-424.

[27]ZHAO X S,GAO L,WANG J,et al.A novel ginsenoside Rb1-hydrolyzing β-D-glucosidase from Cladosporium fulvum[J].Process Biochemistry,2009,44(6):612-618.

[28]SHIN K C,LEE G W,OH D K.Production of ginsenoside Rd from ginsenoside Rc by α-L-arabinofuranosidase from Caldicellulosiruptor saccharolyticus[J].Journal of Microbiology and Biotechnology,2013,23(4):483-488.

[29]SON J W,KIM H J,OH D K.Ginsenoside Rd production from the major ginsenoside Rb1 by β-glucosidase from Thermus caldophilus[J].Biotechnology Letters,2008,30(4):713-716.

[30]GAO J,HU Y B,JI L,et al.A novel ginsenoside-hydrolyzing enzyme from Penicillium oxalicum and its application in ginsenoside Rd production[J].Biocatalysis and Biotransformation,2013,31(6):305-312.

[31]YAN Q,ZHOU W,SHI X L,et al.Biotransformation pathways of ginsenoside Rb1 to compound K by β-glucosidases in fungus Paecilomyces Bainier sp.229[J].Process Biochemistry,2010,45(9):1550-1556.

[32]GAO J,ZHAO X S,LIU H B,et al.A highly selective ginsenoside Rb1-hydrolyzing-β-glucosidase from Cladosporium fulvum[J].Process Biochemistry,2010,45(6):897-903.

[33]YE L,ZHOU C Q,ZHOU W,et al.Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant Paecilomyces Bainier 229-7[J].Bioresource Technology,2010,101(20):7872-7876.

[34]CHEN G T,YANG M,SONG Y,et al.Microbial transformation of ginsenoside Rb1 by Acremonium strictum[J].Applied Microbiology and Biotechnology,2008,77(6):1345-1350.

[35]TEN L N,CHAE S M,YOO S A.Biotransformation of ginsenoside Rb1 into Rd by the bacterium Lysobacter panaciterrae[J].Chemistry of Natural Compounds,2013,49(4):773-774.

[36]ZHAO X,WANG J,LI J,et al.Highly selective biotransformation of ginsenoside Rb1 to Rd by the phytopathogenic fungus Cladosporium fulvum (syn.Fulvia fulva)[J].Journal of Industrial Microbiology and Biotechnology,2009,36(5):721-726.

[37]ZHANG W,SUN X D,ZHANG P,et al.Screening of the active fungal strains with high specificity to biotransform ginsenoside Rb1 into Rd[J].Mycosystema,2011,30(2):305-311.

[38]KIM H,KIM J H,LEE P Y,et al.Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum[J].Journal of Microbiology and Biotechnology,2013,23(12):1802-1805.

Memo

Memo:
-
Last Update: 2016-01-18