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Research Progress of the Production of Camptothecin(s) Drugs by in vitro Cultures(PDF)

《北方园艺》[ISSN:1001-0009/CN:23-1247/S]

Issue:
2014年12期
Page:
181-184
Research Field:
Publishing date:

Info

Title:
Research Progress of the Production of Camptothecin(s) Drugs by in vitro Cultures
Author(s):
PAN Xue-wuDONG Yan-ling
Department of Biological Sciences and Biotechnology,Wuhan Bioengineering Institute,Wuhan,Hubei 430415
Keywords:
camptothecinin vitro cultureantitumor drugs
PACS:
R 282.1
DOI:
-
Abstract:
In vitro cultures for the production of antitumor drugs-camptothecin(s) were introduced in this article,the focal point of which was the production of camptothecin and its analogues via in vitro cultures such as plant cell culture,hairy root cultures and endophytic fungi cultures.

References:

[1]   Kumar V,Rai S,Gaur P.Endophytic fungi:novel sources of anticancer molecules[M].In:Verma V C and Gange A C.(eds.),Advances in Endophytic Research,Springer India,2014:389-422.
[2]   Wall M E,Wani M C,Cooke C E,et al.Plant antitumor agents,the isolation and structure of camptothecin,a novel alkaloidal leukaemia and tumor inhibitor from Camptotheca acuminate[J].Journal of the American Chemical Society,1966,88:3888-3890.
[3]   Hisang Y H,Herizberg R,Hecht S,et al.Camptothecin induces protein linked DNA breaks via mammalian DNA topoisomerase I[J].The Journal of Biological Chemistry,1985,260:14873-14878.
[4]   Asano T,Kobayashi K,Kashihara E,et al.Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila[J].Phytochemistry,2013,91:128-139.
[5]   Asano T,Sait K,Yamazaki M.Chapter 3,Camptothecin production and biosynthesis in plant cell cultures[J].Recent Advances in Phytochemistry,2013,43:43-54.
[6]   Sakato K,Tanaka H,Mukai N,et al.Isolation and identification of camptothecin from cells of Camptotheca acuminat a suspension cultures[J].Agricultural and Biological Chemistry,1974,38:217-218.
[7]   Van Hengel A J,Harkes M P,Wichers H J,et al.Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminata[J].Plant Cell,Tissue and Organ Culture,1992,28:11-18.
[8]   Wiedenfeld H,Furmanowa M,Roeder E,et al.Camptothecin and 10-hydroxycamptothecin in callus and plantlets of  Camptotheca acuminata[J].Plant Cell,Tissue and Organ Culture,1997,49:213-218.
[9]   Song S H,Byun S Y.Characterization of cell growth and camptothecin production in cell cultures of Camptotheca acuminata[J].Journal of Microbiology and Biotechnology,1998(8):631-638.
[10] Kim S H,Hur B K,Byum S Y.Effect of sugar concentration on camptothecin production in cell suspension cultures of Camptotheca acuminata[J].Biotechnology and Bioprocess Engineering,1999(4):277-280.
[11] Pan X W,Xu H H,Liu X,et al.Improvement of growth and camptothecin yield by altering nitrogen source supply in cell suspension cultures of Camptotheca acuminata[J].Biotechnology Letters,2004,26:1745-1748.
[12] Pan X W,Shi Y Y,Liu X,et al.Influence of inorganic microelements on the production of camptothecin with suspension cultures of Camptotheca acuminata[J].Plant Growth Regulation,2004,44:5963.
[13] 潘学武,董妍玲,石亚亚.真菌诱导子和抗褐变剂对喜树悬浮细胞生长及喜树碱生物合成的影响[J].中国农学通报,2010,26:21-26.
[14] Pi Y,Jiang K,Lin J,et al.Effects of over-expression of allene oxide cyclase on camptothecin production by cell cultures of Camptotheca acuminata[J].African Journal of Biotechnology,2012(11):6535-6541.
[15] Karwasara V S,Dixit V K.Culture medium optimization for camptothecin production in cell suspension cultures of Nothapodytes nimmoniana (J.Grah.) Mabberley[J].Plant Biotechnology Report,2013(7):357-369.
[16] Roja G,Heble M R.The Quinoline alkaloids camptothecin and 9-methoxy camptothecin from tissue cultures and mature trees of Nothapodytes foetida[J].Phytochemistry,1994,36:65-66.
[17] Fulzele D P,Satdive R K,Pol B B.Growth and production of camptothecin by cell suspension cultures of Nothapodytes foetida[J].Planta Medica,2001,67:150-152.
[18] Thengane S R,Kulkarni D K,Shrikhande V A,et al.Influence of medium composition on callus induction and camptothecin(s) accumulation in Nothapodytes foetida[J].Plant Cell,Tissue and Organ Culture,2003,72:247-251. 
[19] Saito K,Sudo H,Yamazaki M,et al.Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila[J].Plant Cell Reports,2001,20:267-271.
[20] Sudo H,Yamakawa T,Yamazaki M,et al.Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila[J].Biotechnology Letters,2002,24:359-363.
[21] Asano T,Watase I,Sudo H,et al.Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O.kuroiwai[J].Plant Biotechnology,2004,21:275-281.
[22] Asano T,Sudo H,Yamazaki M,et al.Camptothecin Production by In Vitro Cultures and Plant Regeneration in Ophiorrhiza Species[M]//S.Mohan Jain and Praveen K.Saxena (eds.),Methods in Molecular Biology,Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants.Humana Press,2009,547:337-345.
[23] Lorence A,MedinaBoliva F,Nessler C L.Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots[J].Plant Cell Reports,2004,22:437-441.
[24] 王伟,陆杨,李礼,等.喜树毛状根的诱导及其喜树碱含量分析[J].西北植物学报,2008,28(12):2416-2422.
[25] Mohana Kumara P,Shweta S,Vasanthakumari M M,et al.Endophytes and Plant Secondary Metabolite Synthesis:Molecular and Evolutionary Perspective[M].In:Verma V C and Gange A C.(eds.),Advances in Endophytic Research,Springer India,2014:177-190.
[26] 闵长莉,汪学军.喜树产10-羟基喜树碱内生真菌的分离鉴定[J].西北植物学报,2009,29(3):614-617.
[27] 闵长莉,袁萍.喜树内生真菌的分离及产10-羟基喜树碱菌的鉴定[J].华东师范大学学报(自然科学版),2009,40(5):94-99.
[28] Kusari S,Zuhlke S,Spiteller M.An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues [J].Journal of Natural Products,2009,72:2-7.
[29] Liu K H,Ding X W,Deng B W,et al.10-Hydroxycamptothecin produced by a new endophytic Xylaria sp.,M20,from Camptotheca acuminata[J].Biotechnology Letters,2010,32:689-693.
[30] Pu X,Qu X,Chen F,et al.Camptothecin-producing endophytic fungus Trichoderma atroviride LY357:isolation,identification,and fermentation conditions optimization for camptothecin production[J].Applied Microbiology and Biotechnology,2013,97:9365-9375.
[31] Kusari S,Zühlke S,Spiteller M.Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis[J].Journal of Natural Products,2011,74:764-775.
[32] 蒲祥,李光州,肖青,等.产喜树碱的喜树内生真菌Aspergillus sp.LY013的分离、退化及退化后的次级代谢产物[J].应用与环境生物学报,2013,19:787-793.
[33] Ding X,Liu K,Deng B,et al.Isolation and characterization of endophytic fungi from Camptotheca acuminata[J].World Journal of Microbiology and Biotechnology,2013,29:1831-1838.
[34] Puri S C,Verma V,Amna T,et al.An endophytic fungus from Nothapodytes foetida that produces Camptothecin[J].Journal of Natural Products,2005,68:1717-1719.
[35] Amna T,Puri S C,Verma V,et al.Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin[J].Canadian Journal of Microbiology,2006,52:189-196.
[36] Rehman S,Shawl A S,Kour A,et al.Comparative studies and identification of camptothecin produced by an endophyte at shake flask and bioreactor[J].Natural Product Research,2009,23:1050-1057.
[37] Shweta S,Zuehlke S,Ramesha B T,et al.Endophytic fungal strains of Fusarium solani,from Apodytes dimidiata E.Mey.Ex Arn (Icacinaceae) produce camptothecin,10-hydroxycamptothecin and 9-methoxycamptothecin[J].Phytochemistry,2010,71:117-122.
[38] Shweta S,Gurumurthy B R,Ravikanth G,et al.Endophytic fungi from Miquelia dentate Bedd produce the anti-cancer alkaloid,camptothecine[J].Phytomedicine,2013,20:337-342.
[39] Shweta S,HimaBindu J,Raghu J,et al.Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecine from Miquelia dentata Bedd (Icacinaceae)[J].Phytomedicine,2013,20:913-917.

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Last Update: 2014-08-02