‘Dongnong 721’ is a new mid-later maturing tomato F1 hybrid,developed by crossing 05HN10 as female parent and 05HN17 as male parent.It is high resistant to ToMV,leaf mold,fusarium wilt and verticillium wilt.The fruit is of large size.The average single fruit weight is 200～220 g.The color of mature fruit is red with regular shape.The average firmness is 0.59 kg/cm2.It has good commodity character for storage and transportation.The shelf life is more than 20 days.The average yield in protected field is 11 000 kg/667m2.It is suitable for cultivation in protected fields in China.