‘Guimi 12’variety of muskmelon was used as materials，vigor，yield，quality，disease and insect pests，and economic benefits in the spring and summer growing of two cultivation conditions that planted in vinyl-house and open cultivation condition were evaluated.The results showed that ‘Guimi 12’ variety of muskmelon in vinyl house production were 31 885.0～32 816.0 kg/hm2，significantly higher than in open cultivation production.The soluble carbonate hydrate content was 16.2%~16.5% higher than 0.2~1.8 percent in open field.The first crop of vinyl house profit increased than open cultivation profit，which were 82 169.95 yuan/hm2, the second crop of vinyl house profit were less than open cultivation profit，which were 20 318.65 yuan/hm2.Investment cost of the muskmelon was less and the fruit was good quality in open field.Because of impact climate，it was high-risk and high-profit，the muskmelon planting in vinylhouse were more reliability in Guangxi.