Taking banana skin as raw material,with the absorbance at 410 nm as the index,the baseacid method,ultrasonic assisted extraction and enzymeultrasonic double auxiliary extraction was discussed,which was more fit for melanin,by the orthogonal test,in order to optimize the extraction technology of melanin from banana skin,and provide theoretical guidance for industrialization production.The results showed that base acid method optimum conditions were hydrochloric acid soaking time 0 h,extracting time 20 min,alkaline solution pH=14,extraction temperature 70℃,absorbance value 0.295 A；ultrasonic assisted extraction optimum conditions were ultrasonic time 10 min,ultrasonic power 100 W,alkaline solution pH=14,hydrochloric acid soaking time 0 h,extracting time 20 min,extraction temperature 70℃,absorbance value 0.573 A；enzyme ultrasonic double auxiliary extraction optimum conditions were cellulase and pectinase synergy,enzyme action time 1.5 h,enzyme action environment pH=4,alkaline solution pH=14,ultrasonic power 100 W,ultrasonic time 10 min,hydrochloric acid soaking time 0 h,extracting time 20 min,extraction temperature 70℃,absorbance value 0.923 A.In conclusion,enzymeultrasonic double auxiliary extraction was ideal industrialize production process for melanin extracted form banana skin.