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Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release(PDF)

《北方园艺》[ISSN:1001-0009/CN:23-1247/S]

Issue:
2012年19期
Page:
175-178
Research Field:
Publishing date:

Info

Title:
Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release
Author(s):
YU Lian; LIU Si-jia; DU Yan; PING Yang; HU Yan-qiu; MA Li-na
Heilongjiang Key Lab of University，College of Pharmaceutical，Jiamusi University，Jiamusi，Heilongjiang 154007
Keywords:
silymarin; solid lipid nanoparticles; emulsification ultrasonic dispersion method
PACS:
S 567.9
DOI:
-
Abstract:
Taking monostearin lipid as material，soybean lecithin and poloxamer 188 as emulsifier，silymarin as a model drug，SM-SLN were prepared by the emulsification ultrasonic dispersion method.The particle size，morphology，encapsulation efficiency，drug loading，in vitro release and stability were studied.The results showed that morphology of SM-SLN was round and smooth，and the average particle size was 150.6 nm and encapsulation efficiency 85.3%.Emulsification ultrasonic dispersion method was suitable for SM-SLN preparation，with high encapsulation efficiency，uniform particle size distribution and better stability.

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Last Update: 2014-09-09