Mycogone perniciosa Magn. is a kind of soil fungus.It is the main source of infection risk of Agaricus bisporus and has been one of the main harmful factors which restricted the production of Agaricus bisporus.The integrated control technology could effectively control the hazards of warts spore mildew of Agaricus bisporus, such as strict treatment of mushroom house,culture medium secondary fermentation,attention to disinfection of the soil,the timing of planting season,strengthening the cultivation and management,selection of strong resistance of mushroom strains and etc.