GU Xupeng,YANG Linlin,DONG Chengming,et al.Research Progress on Quality Formation Mechanism and Regulation of Chinese Herbal Materials[J].Northern Horticulture,2024,(6):129-136.[doi:10.11937/bfyy.20231386]
中药材品质形成机制及调控研究进展
- Title:
- Research Progress on Quality Formation Mechanism and Regulation of Chinese Herbal Materials
- 文章编号:
- 1001-0009(2024)06-0129-09
- 分类号:
- R 282.2
- 文献标志码:
- A
- 摘要:
- 保证中药材质量安全、有效、稳定、可控是中药材产业健康发展的首要前提。近年来中药材需求量日趋增加，由于中药材品质受生态环境（外因）与遗传背景（内因）的综合影响，因此探究中药材品质形成机制对推动中药材质量稳定、可控具有重要的现实意义。该研究通过梳理近年来有关中药材品质形成及环境调控的文献，阐述中药材“道地性”成因、中药材品质形成机制及环境调控研究进展，初步探讨了中药材品质形成相关假说，借此诠释道地药材品质形成的科学内涵，以期为中药材规范化、生态化种植关键技术提升提供参考依据。
- Abstract:
- Ensuring that the quality,safety，effectiveness，stability and controllability of Chinese herbal medicines is the primary premise for the healthy development of the Chinese herbal medicine industry.In recent years，the demand for Chinese herbal medicines has been increasing day by day.Since the quality of Chinese herbal medicines is affected by the ecological environment (exogenous factors) and genetic background (interal factors)，it was of great practical significance to explore the formation mechanism of Chinese herbal medicines quality to promote the quality of Chinese herbal medicines in a stable and controllable way.The study combed through the recent literature on the quality formation of Chinese herbal medicines and environmental regulation，elaborated on the causes of the ‘genuineness’ of Chinese herbal medicines，the formation mechanism of Chinese herbal medicines quality and the progress of environmental regulation，and preliminarily discusses the of the hypotheses related on the quality formation of Chinese herbal medicines，thereby interpreting the scientific connotation of the formation of the quality of authentic Chinese herbal medicines，with a view to providing the key technology of standardised and ecological cultivation of Chinese herbal medicines and the development of the quality control mechanism of Chinese herbal medicines.This is to explain the scientific meaning of the quality formation of genuineness herbs，so as to provide theoretical reference for the improvement of the key technology of standardised and ecological cultivation of Chinese herbal medicines.
参考文献/References:
［1］贾贝田,刘海朝,王怡杨,等.提升中药材品质 紧抓中医临床循证:张伯礼院士谈中医药高质量发展的关键［J］.中国中西医结合杂志,2023,43(1):21-23.［2］万修福,王升,康传志,等.“十四五”期间中药材产业趋势与发展建议［J］.中国中药杂志,2022,47(5):1144-1152.［3］孟祥才,沈莹,杜虹韦.道地药材概念及其使用规范的探讨［J］.中草药,2019,50(24):6135-6141.［4］杨利民.中药材生态种植理论与技术前沿［J］.吉林农业大学学报,2020,42(4):355-363.［5］黄璐琦,陈美兰,肖培根.中药材道地性研究的现代生物学基础及模式假说［J］.中国中药杂志,2004,29(6):494-496,610.［6］赵露颖,施梦瑶,张巧艳,等.道地药材品质特征及形成机制研究进展［J］.中草药,2022,53(21):6931-6947.［7］何冬梅,王海,陈金龙,等.中药微生态与中药道地性［J］.中国中药杂志,2020,45(2):290-302.［8］杨利民.中药资源生态学及其科学问题［J］.吉林农业大学学报,2008,30(4):506-510,537.［9］杨利民,张永刚,林红梅,等.中药材质量形成理论与控制技术研究进展［J］.吉林农业大学学报,2012,34(2):119-124,129.［10］肖小河,夏文娟,陈善墉.中国道地药材研究概论［J］.中国中药杂志,1995,20(6):323-326.［11］肖小河.中药材品质变异的生态生物学探讨［J］.中草药,1989,20(8):42-46.［12］王永炎,张文生.中药材道地性研究状况与趋势［J］.湖北民族学院学报(医学版),2006,23(4):1-4.［13］黄林芳,付娟,陈士林.中药材生态变异的学术探讨［J］.中草药,2012,43(7):1249-1258.［14］袁媛,周骏辉,黄璐琦.黄芩道地性形成“逆境效应”的实验验证与展望［J］.中国中药杂志,2016,41(1):139-143.［15］黄璐琦,郭兰萍,华国栋,等.道地药材的属性及研究对策［J］.中国中医药信息杂志,2007,14(2):44-46.［16］何霖,李福兵,杨晓东.地理、人文与甘肃道地药材［J］.中药与临床,2010,1(3):46-50.［17］游元元,李羿,钟世红,等.史地人文视角下的道地药材［J］.南京中医药大学学报(社会科学版),2014,15(1):17-20.［18］黄璐琦,张瑞贤.“道地药材”的生物学探讨［J］.中国药学杂志,1997,32(9):563-566.［19］曾凡琳,温美佳,王欢,等.道地药材气候生态位研究［J］.时珍国医国药,2016,27(5):1227-1230.［20］黄林芳,郑司浩,武拉斌,等.基于化学成分及分子特征中药材肉苁蓉生态型研究［J］.中国科学:生命科学,2014,44(3):318-328.［21］黄林芳,索风梅,宋经元,等.中国产西洋参品质变异及生态型划分［J］.药学学报,2013,48(4):580-589.［22］KIM N H,JAYAKODI M,LEE S C,et al.Genome and evolution of the shade-requiring medicinal herb Panax ginseng［J］.Plant Biotechnology Journal,2018,16(11):1904-1917.［23］XU J，CHU Y，LIAO B,et al.Panax ginseng genome examination for ginsenoside biosynthesis［J］.GigaScience,2017,6(11):1-15.［24］YAN L，WANG X，LIU H,et al.The genome of Dendrobium officinale illuminates the biology of the important traditional Chinese orchid herb［J］.Molecular Plant,2015,8(6):922-934.［25］ZHANG G Q,XU Q,BIAN C,et al.The Dendrobium catenatum Lindl.genome sequence provides insights into polysaccharide synthase，floral development and adaptive evolution［J］.Scientific Reports,2016,1(6):19029.［26］FU Y,LI L,HAO S,et al.Draft genome sequence of the Tibetan medicinal herb Rhodiola crenulata［J］.GigaScience,2017,6(6):1-5.［27］SHEN Q,ZHANG L,LIAO Z,et al.The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis［J］.Molecular Plant,2018,11(6):776-788.［28］ZHAO Q，YANG J，CUI M Y,et al.The reference genome sequence of Scutellaria baicalensis provides insights into the evolution of wogonin biosynthesis［J］.Molecular Plant,2019,12(7):935-950.［29］MOCHIDA K，SAKURAI T，SEKI H,et al.Draft genome assembly and annotation of Glycyrrhiza uralensis，a medicinal legume［J］.The Plant Journal:For Cell and Molecular Biology,2017,89(2):181-194.［30］SUN W,LENG L,YIN Q,et al.The genome of the medicinal plant Andrographis paniculata provides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide［J］.The Plant Journal:For Cell and Molecular Biology,2019,97(5):841-857.［31］LI L,JOSEF B A,LIU B,et al.Three-dimensional evaluation on ecotypic diversity of traditional Chinese medicine:A case study of Artemisia annua L［J］.Frontiers in Plant Science,2017(8):1225.［32］谢彩香,索风梅,贾光林,等.人参皂苷与生态因子的相关性［J］.生态学报,2011,31(24):7551-7563.［33］YUAN Y,HAO J D,YANG B,et al.Climate change affected the best producing area of Chinese herbal medicine Scutellaria baicalensis Georgi［J］.Journal of Traditional Chinese Medical Sciences,2010(15):241-248.［34］CHENG L,HAN M,YANG L M,et al.Changes in the physiological characteristics and baicalin biosynthesis metabolism of Scutellaria baicalensis Georgi under drought stress［J］.Industrial Crops and Products,2018,122:473-482.［35］程林.干旱胁迫黄芩生理生态变化及其黄芩苷生物合成的分子生态机制［D］.长春:吉林农业大学,2018.［36］谭勇,梁宗锁,董娟娥,等.水分胁迫对菘蓝生长发育和有效成分积累的影响［J］.中国中药杂志,2008,33(1):19-22.［37］黎开强,吴卫,郑有良,等.温度对川贝母生理指标、鳞茎产量及总生物碱含量的影响［J］.中国中药杂志,2008,33(16):1948-1951.［38］周洁,郭兰萍,张霁,等.药用植物对干旱胁迫的响应及受控实验［J］.中国中药杂志,2010,35(15):1919-1924.［39］马莹,郭娟,毛亚平,等.药用植物有效成分生物合成途径解析及其应用［J］.中华中医药杂志,2017,32(5):2079-2083.［40］黄涵签,王潇晗,付航,等.柴胡属药用植物资源研究进展［J］.中草药,2017,48(14):2989-2996.［41］霍梦逸,刘新,林於,等.柴胡挥发油中有效解热成分的研究［J］.药物分析杂志,2013,33(7):1202-1209.［42］杨庆珍,刘德旺,王冬梅,等.黄芪生态型与品质的相关性研究［J］.中草药,2014,45(16):2395-2399.［43］李卫萍,魏长玲,张琛武,等.紫苏栽培种质的形态分类及化学型关系研究［J］.中国中药杂志,2019,44(3):454-459.［44］黄璐琦,郭兰萍.环境胁迫下次生代谢产物的积累及道地药材的形成［J］.中国中药杂志,2007,32(4):277-280.［45］张春荣,桑雪雨,渠萌,等.基于转录组测序揭示适度干旱胁迫对甘草根基因表达的调控［J］.中国中药杂志,2015,40(24):4817-4823.［46］渠萌.适度干旱胁迫对甘草黄酮类化合物积累及相关基因表达的调控［D］.广州:广东药学院,2015.［47］张文婷.淡黄花百合响应热胁迫的分子机制和遗传转化研究［D］.武汉:华中农业大学,2020.［48］江海燕,杜菊花,史俐莎,等.植物高温胁迫响应分子机制研究［J］.分子植物育种,2021,19(3):1022-1030.［49］HE J,YAO L,PECORARO L,et al.Cold stress regulates accumulation of flavonoids and terpenoids in plants by phytohormone，transcription process，functional enzyme，and epigenetics［J］.Critical Reviews in Biotechnology,2023,43(5):680-697.［50］陈顺钦,袁媛,罗毓健,等.光照对黄芩黄酮类活性成分积累及其相关基因表达的影响［J］.中国中药杂志,2010,35(6):682-685.［51］杨兆春,袁媛,陈敏,等.PEG胁迫对黄芩黄酮类有效成分积累及相关基因表达的影响［J］.中国中药杂志,2011,36(16):2157-2161.［52］YUAN Y,LIU Y,WU C,et al.Water deficit affected flavonoid accumulation by regulating hormone metabolism in Scutellaria baicalensis Georgi roots［J］.PLoS One,2012,7(10):e42946.［53］秦双双,陈顺钦,黄璐琦,等.水分胁迫对黄芩内源激素与有效成分相关性的影响［J］.中国实验方剂学杂志,2010,16(7):99-101.［54］YUAN Y,WU C,LIU Y,et al.The Scutellaria baicalensis R2R3-MYB transcription factors modulates flavonoid biosynthesis by regulating GA metabolism in transgenic tobacco plants［J］.PLoS One,2013,8(10):e77275.［55］YUAN Y,QI L,YANG J,et al.A Scutellaria baicalensis R2R3-MYB gene，SbMYB8，regulates flavonoid biosynthesis and improves drought stress tolerance in transgenic tobacco［J］.Plant Cell,Tissue and Organ Culture (PCTOC),2015,120(3):961-972.［56］LU X,SHEN Q,ZHANG L,et al.Promotion of artemisinin biosynthesis in transgenic Artemisia annua by overexpressing ADS，CYP71AV1 and CPR genes［J］.Industrial Crops and Products,2013,49:380-385.［57］LV Z,ZHANG F,PAN Q,et al.Branch pathway blocking in Artemisia annua is a useful method for obtaining high yield Artemisinin［J］.Plant and Cell Physiology,2016,57(3):588-602.［58］MA Y N,XU D B,LI L,et al.Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua［J］.Science Advances,2018,4(11):s9357.［59］HAO X,ZHONG Y,NTZMANN H W,et al.Light-induced artemisinin biosynthesis is regulated by the bzip transcription factor AaHY5 in Artemisia annua［J］.Plant and Cell Physiology,2019,60(8):1747-1760.［60］YAN T,CHEN M,SHEN Q,et al.Homeodomain protein 1 is required for jasmonate-mediated glandular trichome initiation in Artemisia annua［J］.The New Phytologist,2017,213(3):1145-1155.［61］FU X,SHI P,HE Q,et al.AaPDR3，a PDR transporter 3，is involved in sesquiterpene β-caryophyllene transport in Artemisia annua［J］.Frontiers in Plant Science,2017(8):723.［62］张涛.人参及其皂苷生物合成对低温的生理生态响应机制研究［D］.长春:吉林农业大学,2019.［63］杨林林.北柴胡中柴胡皂苷合成积累对水分调控响应的分子生态机制研究［D］.长春:吉林农业大学,2020.［64］YANG L L,YANG L,YANG X,et al.Drought stress induces biosynthesis of flavonoids in leaves and saikosaponins in roots of Bupleurum chinense DC［J］.Phytochemistry,2020,177:112434.［65］YANG L L,YANG L,LAN Y M,et al.Exogenous abscisic acid reduces saikosaponin accumulation by inhibiting saikosaponin synthesis pathway gene expression under drought stress in Bupleurum chinense DC［J］.Industrial Crops and Products,2020,154:112686.［66］郭兰萍,王铁霖,杨婉珍,等.生态农业:中药农业的必由之路［J］.中国中药杂志,2017,42(2):231-238.［67］郭兰萍,周良云,莫歌,等.中药生态农业:中药材GAP的未来［J］.中国中药杂志,2015,40(17):3360-3366.
相似文献/References:
[1]冯绍平,黄兆龙,李自静,等.巯基棉富集-原子吸收法测定不同中药材中镉和铅[J].北方园艺,2014,38(13):162.
FENG Shao-ping,HUANG Zhao-long,LI Zi-jing,et al.Determination of Cadmium and Lead in Different Chinese Herbal Medicine by Separating and Enriching With Sulfhydryl Cotton-Flame Atomic Absorption Spectrometry[J].Northern Horticulture,2014,38(6):162.
[2]吴朝峰,马雪梅.河南省中药材生产现状及对策研究[J].北方园艺,2014,38(07):178.
WU Chao-feng,MA Xue-mei.The Production Situation and Countermeasures of Chinese Herbal Medicine in Henan Province[J].Northern Horticulture,2014,38(6):178.
[3]史艳财,李承卓,邹蓉,等.中药材间作种植模式研究进展[J].北方园艺,2012,36(16):180.
SHI Yan-cai,LI Cheng-zhuo,ZOU Rong,et al.Advances in Study on Compound Planting Models of Chinese Traditional Medicinal Herbs[J].Northern Horticulture,2012,36(6):180.
[4]张新权,付国赞,孙丽峥,等.适宜与仁用杏间作的中药材品种筛选研究[J].北方园艺,2012,36(24):171.
ZHANG Xin-quan,FU Guo-zan,SUN Li-zheng,et al.Research of Variety Selection on the Intercropping System of Kernel-used Apricot and Chinese Medicinal Plants[J].Northern Horticulture,2012,36(6):171.
[5]李娅.基于SWOT分析的云南省中药材产业发展战略研究[J].北方园艺,2014,38(17):180.
LI Ya.Development Strategy of Chinese Herbal Medicine Industry in Yunnan Province Based on SWOT Analysis[J].Northern Horticulture,2014,38(6):180.
[6]崔旭盛,解军波,张彦青,等.基于供需曲线的中药材市场价格影响分析[J].北方园艺,2019,43(23):152.[doi:10.11937/bfyy.20192684]
CUI Xusheng,XIE Junbo,ZHANG Yanqing,et al.Analysis of Market Price Influence of Chinese Herbal Medicine Based on Supply and Demand Curve[J].Northern Horticulture,2019,43(6):152.[doi:10.11937/bfyy.20192684]
[7]崔旭盛,丁颖辉,高秀强,等.基于多元线性回归模型的中药材市场价格分类预测实证研究[J].北方园艺,2020,44(14):157.[doi:10.11937/bfyy.20193701]
CUI Xusheng,DING Yinghui,GAO Xiuqiang,et al.Empirical Study on Market Price Classification and Prediction of Traditional Chinese Medicine Based on Multiple Linear Regression Model[J].Northern Horticulture,2020,44(6):157.[doi:10.11937/bfyy.20193701]
[8]贾悦,杨钰泽,王建忠.河北省新型中药材产业模式研究[J].北方园艺,2021,(04):139.[doi:10.11937/bfyy.20202035]
JIA Yue,YANG Yuze,WANG Jianzhong.Research on the Industurial Model of New Type Chinese Medicinal Materials in Hebei Province[J].Northern Horticulture,2021,(6):139.[doi:10.11937/bfyy.20202035]
[9]崔旭盛,李鑫,宗建新,等.基于GARCH族模型的中药材市场连翘价格波动分析[J].北方园艺,2021,(04):144.[doi:10.11937/bfyy.20193990]
CUI Xusheng,LI Xin,ZONG Jianxin,et al.Analysis of Forsythia suspensa Price Fluctuation in Traditional Chinese Medicine Market Based on GARCH Family Models[J].Northern Horticulture,2021,(6):144.[doi:10.11937/bfyy.20193990]
[10]苗祯,章亚东,陈彦亮.河南省中药材产业SWOT分析及对策建议[J].北方园艺,2021,(24):142.[doi:10.11937/bfyy.20212559]
MIAO Zhen,ZHANG Yadong,CHEN Yanliang.SWOT Analysis and Countermeasures of Traditional ChineseMedicine Industry in Henan Province[J].Northern Horticulture,2021,(6):142.[doi:10.11937/bfyy.20212559]
备注/Memo
第一作者简介：顾旭鹏（1998-），男，硕士研究生，研究方向为中药资源与鉴定。E-mail：2321665159@qq.com.责任作者：杨林林（1992-），男，博士，讲师，现主要从事药用植物栽培生理与生态学等研究工作。E-mail：yangll-hatcm@hactcm.edu.cn.基金项目：国家自然科学基金资助项目(82104329)。收稿日期：2023-04-22